姓名:宋立华
职称:见习教授
邮箱:songlihua@mail.buct.edu.cn
办公地址:西校区教学楼415b |
教育背景:
2001.8-2006.6 军事医学科学院,博士 (军事预防医学专业)
1997.9-2001.7 山东大学生命科学学院,学士(微生物学专业)
工作经历:
2010.7-2013.6 美国nih/niaid/rml博士后
2009.9-2018.7 军事医学科学院微生物流行病研究所,副研究员
2019.1-至今 北京化工大学生命科学与技术学院,见习教授
学术**:
1.中国**共患病学报编委
2.中国**共患病学会衣原体学组副组长
3.中国衣原体学会学术委员
4.国家自然科学基金函审专家
5.frontiers in microbiology和frontiers in immunology等杂志reviewer editor
主要研究领域:
重要病原微生物的防治技术与致病机制。重点关注新发突发病毒病、专性胞内寄生菌和多重耐药菌等。采用生物化学、生物信息学、合成生物学等多学科方法,开展传染病防控新技术新方法研究。目前的主要研究方向有:
1.q热立克次体培养新方法。
2.沙眼衣原体pgp4调控基因转录机制。
3.新发病毒病的流行病学分析。
获奖及荣誉:
2016年,高致病性病原微生物检测鉴定新技术和装备,国家科技进步二等奖,排名第七
2015年,呼吸道、肠道新发病毒性传染病病原体及防控技术研究,军队医疗成果一等奖,排名第二
2013年,鹦鹉热衣原体基因工程疫苗及快速检测试剂,国家技术发明二等奖,排名第三
2011年,禽畜鹦鹉热衣原体基因工程亚单位疫苗和检测技术的研究,北京市科技进步一等奖,排名第三
科研项目:
1.国家自然科学基金国际合作研究项目、3211101856、反刍动物重要新发再发传染病的分子病原学和诊断技术研究、2022/01-2024/12、260万元、主持。
2.北京市科技重大专项项目、z171100000417015、沙眼衣原体减毒活疫苗候选株的研制、2017/03-2019/02、100万元、主持。
3.国家自然科学基金面上项目、31570177、沙眼衣原体质粒编码毒力因子pgp4的致病机理研究、2016/01-2019/12、72.9万元、主持。
4.国家自然科学基金面上项目、81071360、新型呼肠病毒细胞吸附蛋白致病机理的研究、2011/01-2013/12、30万元、已结题、主持。
5.国家自然科学基金青年科学基金项目、30500369、流产嗜衣原体媒介传播机制的探索研究、2006/01-2008/12、25万元、已结题、主持。
代表性著作:
1. 1.shengdong luo#, shanshan lu#, huahao fan#, zeliang chen#, zhihui sun, yan hu, ruisheng li, xiaoping an, vladimir n uversky, yigang tong*, lihua song*. the coxiella burnetii qph1 plasmid is a virulence factor for colonizing bone marrow-derived murine macrophages, journal of bacteriology, 2021, 203(9): e00588-20.
2. 2.huahao fan, liqin wang, wenli liu, xiaoping an, zhendong liu, xiaoqi he, lihua song*, and yigang tong*. repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus (2019-ncov) related coronavirus model. chinese medical journal (english), 2020, 133(9): 1051-1056.
3. 3.tao wang, yonghui yu, xiaofei liang, shengdong luo, zemin he, zhihui sun, yongqiang jiang, anders omsland, pei zhou and lihua song. lipid a has significance for optimal growth of coxiella burnetii in macrophage-like thp-1 cells and to a lesser extent in axenic media and non-phagocytic cells. frontiers in cellular and infection microbiology, 2018, 8: 192. doi: 10.3389/fcimb.2018.00192
4. 4.gail l. sturdevant, claire e. couch, heather s. watkins, linnell b. randall, jillian m. ilgenfritz, lihua song, timothy r. southern, william m. whitmire, harlan d. caldwell, laszlo kari. the developmentally regulated chlamydia trachomatis gene chxr is not essential for in vitro or in vivo growth. pathogens and disease, 2017, 75(3).
5. 5.鲁辛辛, 冯乐, 于永慧, 罗声栋, 孙志会, 王涛, 端青, 王宁利, 宋立华. 青海藏区b型沙眼衣原体的分离培养与鉴定. 微生物学通报, 2017, 44(6): 1444-1450.
6. 6.于永慧, 王涛, 罗声栋, 冯乐, 孙志会, 宋立华. q热性心内膜炎1例抗i相和ii相抗原igg抗体的跟踪检测报道. 军事医学, 2017, 41(2): 160-161.
7. 7.le feng, xinxin lu, yonghui yu, tao wang, shengdong luo, zhihui sun, qing, duan, ningli wang, lihua song. survey, culture, and genome analysis of ocular chlamydia trachomatis in tibetan boarding primary schools in qinghai province, china. frontiers in cellular and infection microbiology, 2017, 6: 207. doi: 10.3389/fcimb.2016.00207.
8. 8.yongfeng lu, jun he, tingting zuo, yanwei li, hong zhu, qing duan, lihua song. phylogeography of francisella tularensis from tibet, china: evidence for an asian origin and radiation of holarctica-type tularemia. ticks tick borne dis, 2016, 7(5): 865-868.
9. 9.chunfu yang, tregei starr, lihua song, john h. carlson, gail l. sturdevant, paul a. beare, william m. whitmire, harlan d. caldwell. chlamydial lytic exit from host cells is plasmid regulated. mbio, 2015, 6(6): e01648-15. doi:10.1128/mbio.01648-15.
10. 10.stephen f. porcel, john h. carlson, daniel e. sturdevant, gail l. sturdevant, kishore kanakabandi, kimmo virtaneva, hannah wilder, william m. whitmire, lihua song, harlan d. caldwell. transcriptional profiling of human epithelial cells infected with plasmid-bearing and plasmid-deficient chlamydia trachomatis. infection and immunity, 2015, 83(2): 534-543.
11. 11.王涛, 宋立华. 贝氏柯克斯体的分子致病机理究进展. 中国**共患病学报, 2015, 31(9): 876-880, 885.
12. 12.gail l. sturdevant, john h. carlson, william m. whitmire, bing zhou, lihua song, and harlan d. caldwell. infectivity of urogenital chlamydia trachomatis plasmid-deficient, ct135-null, and double-deficient strains in female mice [j]. pathogens and disease, 2014, 71(1): 90-92.
13. 13.lihua song, john h. carlson, bing zhou, kimmo virtaneva, william m. whitmire, gail l. sturdevant, stephen f. porcella, grant mcclarty, and harlan d. caldwell. plasmid-mediated transformation tropism of chlamydial biovars [j]. pathogens and disease, 2014, 70(2): 189-193.
14. 14.**, 端青, 宋立华. 衣原体最新分类体系与分类鉴定方法研究进展. 中国**共患病学报, 2014, 30(12): 1262-1266.
15. 15.lihua song, john h. carlson, william m. whitmire, laszlo kari, kimmo virtaneva, daniel e. sturdevant, heather watkins, bing zhou, gail l. sturdevant, stephen f. porcella, grant mcclarty, and harlan d. caldwell. chlamydia trachomatis plasmid-encoded pgp4 is a transcriptional regulator of virulence-associated genes [j]. infection and immunity, 2013, 81(3): 636-44. (commented)
16. 16.lihua song, yan li, guangqiao liu, jun he, hong zhu, and qing duan. genotyping of chlamydophila psittaci strains derived from avian and mammalian species [j]. vet res commun, 2009, 33: 577-580.
17. 17.lihua song, bing zhou, hong zhu, and qing duan. outdoor electric mosquito killing apparatuses for malaria control in a hyperendemic area [j]. clinical infectious diseases, 2009, 49: 480.
教师寄语:
宝剑锋从磨砺出,梅花香自苦寒来。
招生要求:
认真刻苦、热爱科研、执行力强、能阅读英文文献