姓名：范华昊 职称：见习教授 座机：010-64451781
邮箱：fanhuahao.1987@163.com |
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教育背景：
2016年7月毕业于北京大学病原生物学专业，获理学博士学位。
工作经历：
2023.02- 北京化工大学生命科学与技术学院，见习教授
2019.11-2023.01 北京化工大学生命科学与技术学院，副教授
2017.08-2019.10 清华大学医学院，博士后
2016.07-2017.07 北京302医院青少年肝病诊疗中心，助理研究员
主要研究领域：
研究方向一：新发传染病（冠状病毒、肠道病毒）药物筛选及病毒感染宿主分子机制研究
研究方向二：噬菌体基础与临床
获奖及荣誉：
2022年第十五届全国大学生创新创业年会入选项目，指导教师
2020年北京化工大学校长奖“科技抗疫团队奖”，排名第二
2020年度北京化工大学“重要科技进展”，排名第二
学术兼职：
中国医药生物技术协会单克隆抗体专业委员会委员；
中国生物工程学会噬菌体技术专业委员会(筹) 委员；
北京医学会微生物与免疫学分会青年委员；
advanced biology杂志编委；
exploration杂志青年编委；
molecules专刊主编；
frontiers in bioscience-landmark专刊主编；
signal transduction and targeted therapy、briefings in bioinformatics、emerging microbes & infections、journal of infection、frontiers in immunology、journa of medical virology、expert review of anti-infective therapy等期刊审稿人。
目前从事的主要研究工作介绍：
本人主要研究方向为抗病毒药物筛选、新材料、绿色消杀方法及病毒宿主互作机制研究，紧跟领域国际学术前沿，结合学科发展趋势，提炼关键科学问题，开展了系统深入的研究工作，主要研究方向包括：
（1）千金藤素抗新冠病毒的发现与机制研究；
（2）母乳抗新冠病毒的发现与机制研究；
（3）“三药三方”为代表的中药方剂抗新冠病毒的作用机制研究；
（4）等离子体广谱高效消杀冠状病毒研究；
（5）肝炎病毒 hcv 吸附受体在胞间传递中的重要作用及 hev 危险因素分析；
（6）新冠患者的临床特征分析与新冠病毒变异特征、抗病毒药物最新进展系列综述：
（7）噬菌体基础与临床应用
承担项目：
1. jw科技委后勤开放项目，rna病毒感染与传播的动物模型研究课题负责人在研339.5万元在研
2. 合生元（广州）健康产品有限公司，乳源活性成分抗类新冠病毒gx_p2v、肠道病毒ev71与轮状病毒的效果评价课题负责人 80万元在研
3. 生物安全项目，xxx验证研究，课题负责人45万元在研
4. 生物安全项目，xxx机制研究课题负责人 50万元在研
5. 国家自然科学基金委员会青年项目，乳铁蛋白通过靶向s蛋白/rdrp和调节免疫信号通路广谱抑制冠状病毒作用机制研究课题负责人30万元在研
6. 国家科学技术部重点研发计划项目，dna存储中的组合方法子课题负责人68.26万元在研
7. 国家自然科学基金委员会原创项目，千金藤素抗新冠病毒作用机制研究课题骨干156万元在研
8. “国家中医药创新团队-新冠揭榜”项目骨干40万元在研
9. 科技部“十三五”重大专项应急项目“中医药疗法应对delta变异病毒”项目骨干80万元在研
10. 军事医学研究院，细胞模型体外（in vitro）抗新型冠状病毒药物测试课题负责人30万元在研
11. 中关村国际医药检验认证科技有限公司，点而康表面湿巾抗hcv病毒效果评价课题负责人5万元在研
12. 北医三院创新转化基金，一种基于噬菌体的医院环境消毒剂的研发课题负责人 25万元在研
13. 国家卫生计生委国家科技重大专项，登革病毒及寨卡病毒动物-人-动物跨物种传播机制课题骨干 160.53万元已结题
14. 北京市教委，北京高校新冠环境样本检测课题骨干199万元已结题
15. 中央高校基本业务费自由探索项目，新型高致病性犬冠状病毒的进化与致病机制研究课题负责人16.5万元已结题
16. 北京诺安百汇医药科技有限公司，噬菌体技术服务课题骨干 50万元已结题
17. 上海微谱化工技术服务有限公司，冠状病毒灭活检测课题骨干30万元已结题
18. 国家重点研发计划，2019-ncov溯源和传播传播途径研究课题骨干50万元已结题
19. 中国博士后科学基金会面上项目，亚感染剂量寨卡病毒增强病毒对埃及伊蚊再次感染课题负责人 8万元已结题
发表文章（一作和通讯作者）：
主要从事新冠病毒科研攻关和噬菌体基础临床应用。以第一作者和通讯作者发表sci论文50余篇，其中影响因子10分以上19篇，相关期刊主要包括the lancet microbe（1篇，if=86.2）、signal transduction and targeted therapy（6篇，if=38.1）、clinical infectious diseases（1篇，if=20.99）、journal of medical virology（2篇，if=20.8）、emerging microbes and infections （2篇，if=19.568），advanced science（1篇，if=17.521）、journal of hazardous materials（1篇，if=14.2）、briefings in bioinformatics（2篇，if=13.99）、frontiers in immunology（4篇，if=8.8）、journal of virology（4篇，if=6.5）等，授权专利8项，获得2020年北京化工大学校长奖“科技抗疫团队奖”（排名第二）、2020年度北京化工大学重要科技进展（排名第二）、2020年、2022年北京化工大学生命科学与技术学院高水平论文奖（排名第一）。
[1] huahao fan*, liqin wang*, wenli liu*, xiaoping an*, zhendong liu, xiaoqi he, lihua song#,yigang tong#. e 2019 in a 2019-novel coronavirus (2019-ncov) related coronavirus model. chinese medical journal 2020; 133(9):1051-1056. jcr if:6.1; esi高被引论文（被引大于200次）; first author 研究论文
[2] huahao fan#,*, fuxing lou#, junfen fan#, maochen li#, yigang tong*. the emergence of powerful oral anti-covid-19 drugs in the post-vaccine era. the lancet microbe. 2022; 3(2):e91. jcr if:86.2; top journal; first author and co-corresponding author 评论文章
[3] maochen li*, han wang*, lili tian*, zehan pang*, qingkun yang, tianqi huang, junfen fan, lihua song#, yigang tong#, huahao fan#. covid-19 vaccine development: milestones, lessons, and prospects. signal transduction and targeted therapy. 2022; 7(1):146. jcr if:38.1; top journal; corresponding author 长篇综述
[4] yangzhen chen*, maochen li*, huahao fan#. the monkeypox outbreak in 2022: adaptive evolution associated with apobec3 may account for. 2022;7(1):323. jcr if:38.1; top journal; corresponding author评论文章
[5] maochen li*, fuxing lou*, huahao fan#. sars-cov-2 variant omicron: currently the most complete “escapee” from neutralization by antibodies and vaccines. signal transduction and targeted therapy. 2022;7(1):28. jcr if:38.1; esi高被引论文; top journal; corresponding author评论文章
[6] maochen li*, fuxing lou*, huahao fan#. sars-cov-2 variants of concern delta: a great challenge to prevention and control of covid-19. signal transduction and targeted therapy. 2021; 6(1): 349. jcr if:38.1; top journal; corresponding author 评论文章
[7] maochen li*, fuxing lou*, huahao fan#. sars-cov-2 variants: a new challenge to convalescent serum and mrna vaccine neutralization efficiency. signal transduction and targeted therapy. 2021; 6(1):151. jcr if:38.1; top journal; corresponding author 评论文章
[8] huahao fan*, bixia hong*, yuqian luo*, qi peng*, liqin wang, xiangshu jin, yangzhen chen, yunjia hu, yi shi, tong li, hui zhuang, yi-hua zhou#, yigang tong#, kuanhui xiang#. the effect of whey protein on viral infection and replication of sars-cov-2 and pangolin coronavirus in vitro. signal transduction and targeted therapy. 2020; 5(1):275. jcr if:38.1; top journal; first author 封面文章研究论文
[9] lijun sun*, lijun shen*, junfen fan*, fengjun gu, mei hu, yiran an, qing zhou, huahao fan#, jingfeng bi#. clinical features of patients with coronavirus disease 2019 from a designated hospital in beijing, china. journal of medical virology. 2020; 92(10):2055-2066. jcr if:20.7; co-corresponding author 临床研究论文
[10] shi-ting he*, hongbo qin*, lin guan*, ke liu, bixia hong, xiaoxu zhang, fuxing lou, maochen li, wei lin, yangzhen chen, chengzhi he, feitong liu, shanshan lu, shengdong luo, shaozhou zhu, xiaoping an, lihua song, huahao fan#, yigang tong#. bovine lactoferrin inhibits sars-cov-2 and sars-cov-1 by targeting the rdrp complex and alleviates viral infection in the hamster model. journal of medical virology. 2023; 95(1):e28281. jcr if:20.7; co-corresponding author研究论文
[11] lijun sun*, junfen fan*, huiru gao, liying shan, xue li, hui zhuang, and huahao fan#. clinical outcomes in patients with acute hepatitis e: exacerbation by background end-stage liver disease but not pure hepatitis b virus infection. clinical infectious diseases. 2020; 70(12):2747-2748. jcr if:20.99; top journal; corresponding author临床研究论文
[12] shanshan lu, shengdong luo, chang liu, muli li, xiaoping an, mengzhe li, jun hou, huahao fan#, panyong mao#, yigang tong#, lihua song#. induction of significant neutralizing antibodies against sars-cov-2 by a highly attenuated pangolin coronavirus variant with a 104nt deletion at the 3'-utr. emerging microbes and infections. 2023; 12(1):2151383. jcr if: 19.568; top journal; co-corresponding author 研究论文
[13] xiaoxu zhang, bixia hong, peng wei, pengfei pei, haifeng xu, long chen, yigang tong, jialin chen#, shi-zhong luo#, huahao fan#, chengzhi he#. pathogen-host adhesion between sars-cov-2 spike proteins from different variants and human ace2 studied at single-molecule and single-cell levels. emerging microbes and infections. 2022; 11(1):2658-2669. jcr if:19.568; top journal; co-corresponding author 研究论文
[14] hao tang*, hongbo qin*, shiting he, qizhen li, huan xu, mengsi sun, jiaan li, shanshan lu, shengdong luo, panyong mao, pengjun han, lihua song, yigang tong#, huahao fan#, xingyu jiang#. anti-coronaviral nanocluster restrain infections of sars-cov-2 and associated mutants through virucidal inhibition and 3cl protease inactivation. advanced science. 2023; doi: 10.1002/advs.202207098. jcr if:17.521; top journal; co-corresponding author 研究论文
[15] hongbo qin*, hengju qiu*, shi-ting he, bixia hong, ke liu*, fuxing lou, maochen li, pan hu, xianghao kong, yujie song, yuchen liu, mingfang pu, pengjun han, mengzhe li, xiaoping an, lihua song, yigang tong#, huahao fan#, ruixue wang#. efficient disinfection of sars-cov-2 and other coronaviruses using cold plasma induces spike protein damage. journal of hazardous materials. 2022; 430:128414. jcr if:14.2; top journal; corresponding author 研究论文
[16] shasha li*, wenli liu*, yangzhen chen*, liqin wang*, wenlin an, xiaoping an, lihua song, yigang tong#, huahao fan#, chenyang lu#. transcriptome analysis of cepharanthine against a sars-cov-2-related coronavirus. briefings in bioinformatics. 2021; 22(2):1378-1386. jcr if:13.99; top journal; co-corresponding author 研究论文
[17] pengfei pei*, hongbo qin*, jialin chen, fengli wang, chengzhi he, shiting he, bixia hong, ke liu, ren-zhong qiao, huahao fan#, yi-gang tong#, long chen#, shi-zhong luo#. computational design of ultrashort peptide inhibitors of the receptor binding domain (rbd) of the sars-cov-2 s protein. briefings in bioinformatics. 2021; 22(6):bbab243. jcr if:13.99; top journal; co-corresponding author研究论文
[18] shuqi wang*, zehan pang*, huahao fan#, yigang tong#. advances in anti-ev71 drug development research. journal of advanced research. 2023; jcr if:12.82; top journal; co-corresponding author长篇综述
[19] shi-ting he*, kexin wu*, zixuan cheng*, mengjie he*, ruolan hu*, ning fan, lin shen, qirui li, huahao fan#, yigang tong#. long covid: the latest manifestations, mechanisms, and potential therapeutic interventions. medcomm. 2022; 3(4):e196. co-corresponding author 长篇综述即时if>10
[20] ailan xu*, bixia hong*, fuxing lou*, shuqi wang*, wenye li, amna shafqat, xiaoping an, yunwei zhao#, lihua song#, yigang tong#, huahao fan#. sub-lineages of the sars-cov-2 omicron variants: characteristics and prevention. medcomm. 2022; 3(3):e172. co-corresponding author 长篇综述即时if>10
[21] *, *, *, *, , , #, #, #, #. molnupiravir and its antiviral activity against covid-19. frontiers in immunology. 2022; 13:855496. jcr if:8.8; top journal;esi高被引论文corresponding author 长篇综述
[22] yahao li, mingfang pu, pengjun han, mengzhe li, xiaoping an, lihua song, huahao fan#, zeliang chen#, yigang tong#. efficacy in galleria mellonella larvae and application potential assessment of a new bacteriophage buct700 extensively lyse stenotrophomonas maltophilia. microbiology spectrum. 2023; e0403022. jcr if:9.043; top journal; co-corresponding author研究论文
[23] lin jiang, ao tang, lihua song#, yigang tong#, huahao fan#. advances in the development of antivirals for rotavirus infection. frontiers in immunology. 2023; accepted. jcr if:8.8; top journal; corresponding author 长篇综述
[24] yuer wang, huahao fan#, yigang tong#. unveil the secret of bacteria and phages arm race. international journal of molecular sciences. 2023; accepted. jcr if:6.2; top journal; corresponding author 研究论文
[25] ke han*, yuqi dong*, xiaoping an, lihua song, mengzhe li#, huahao fan#, yigang tong#. potential application of a newly isolated phage buct609 infecting stenotrophomonas maltophilia. frontiers in microbiology. 2022; 13:1001237. jcr if:6.1; top journal; co-corresponding author 研究论文
[26] huahao fan*,#, shi-ting he*, pengjun han*, bixia hong*, ke liu*, maochen li*, shuqi wang*, yigang tong#. cepharanthine: a promising old drug against sars-cov-2. advanced biology. 2022; doi: 10.1002/adbi.202200148. jcr if:4.6; co-corresponding author 评论文章
[27] 范华昊*，#，刘珂*，洪碧霞*，何诗婷*，韩鹏军*，李卯晨*，王姝琦*，童贻刚#.千金藤素抗新冠病毒研究进展.南方医科大学学报 2022, 42(6): 955-956 评论文章
[28] zehan pang*, ruolan hu*, lili tian*, fuxing lou*, yangzhen chen, shuqi wang, shiting he, shaozhou zhu, xiaoping an, lihua song#, feitong liu#, yigang tong#, huahao fan#. overview of breastfeeding under covid-19 pandemic. frontiers in immunology. 2022; 13:896068. jcr if:8.8; top journal;corresponding author 长篇综述
[29] mingfang pu*, pengjun han*, guangye zhang, yucong liu, yahao li, fei li, mengzhe li, xiaoping an, lihua song, yiming chen, huahao fan#, yigang tong#. characterization and comparative genomics analysis of a new bacteriophage buct610 against klebsiella pneumoniae and efficacy assessment in galleria mellonella larvae. international journal of molecular sciences. 2022; 23(14):8040. jcr if:6.2; top journal; corresponding author 研究论文
[30] yangzhen chen, yecheng you, shuqi wang, lin jiang, lili tian, shaozhou zhu, xiaoping an, lihua song, yigang tong#, huahao fan#. antiviral drugs screening for swine acute diarrhea syndrome coronavirus. international journal of molecular sciences. 2022; 23, 11250. jcr if:6.2; top journal; corresponding author 研究论文
[31] fuxing lou, ruolan hu, yangzhen chen, mengzhe li, xiaoping an, lihua song, yigang tong#, huhao fan#. 2'-fucosyllactose inhibits coxsackievirus class a type 9 infection by blocking virus attachment and internalization. international journal of molecular sciences. 2022; 23(22):13727. jcr if:6.2; top journal;corresponding author 研究论文
[32] pengjun han, wenjing zhang, mingfang pu, yahao li, lihua song, xiaoping an, mengzhe li, fei li, shuyan zhang#, huahao fan#, yigang tong#. characterization of the bacteriophage buct603 and therapeutic potential evaluation against drug-resistant stenotrophomonas maltophilia in a mouse model. frontiers in microbiology. 2022; 13:906961. jcr if:6.1; top journal; co-corresponding author 研究论文
[33] mingfang pu*, yahao li*, pengjun han, wei lin, ronghua geng, fen qu, xiaoping an, lihua song, yigang tong, shuyan zhang#, zhen cai#, huahao fan#. genomic characterization of a new phage buct541 against klebsiella pneumoniae k1-st23 and efficacy assessment in mouse and galleria mellonella larvae. frontiers in microbiology. 2022; 13:950737. jcr if:6.1; top journal; co-corresponding author 研究论文
[34] fuxing lou*, maochen li*#, zehan pang*, lin jiang*, lin guan*, lili tian, jiaming hu, junfen fan#, huahao fan#. understanding the secret of sars-cov-2 variants of interest/concern and immune escape. frontiers in immunology. 2021; 12:744242. jcr if:8.8; top journal; corresponding author 长篇综述
[35] yahao li, pengjun han, mingfang pu, fei li, mengzhe li, xiaoping an, lihua song, huahao fan#, yigang tong#, zeliang chen#. genomic analysis of the serratia marcescens bacteriophage buct660. microbiology resource announcements. 2022; doi: 10.1128/mra.00406-22. 基因组报告
[36] hunjia hu*, meiqin liu*, hongbo qin*, haofeng lin, xiaoping an, zhengli shi, lihua song#, xinglou yang#, huahao fan#, yigang tong#. artemether, artesunate, arteannuin b, echinatin, licochalcone b and andrographolide effectively inhibit sars-cov-2 and related viruses in vitro. frontiers in cellular and infection microbiology. 2021 doi: 10.3389/fcimb.2021.680127. jcr if:6.1; co-corresponding author 研究论文
[37] huahao fan*,#, junfen fan*, suming chen, yangzhen chen, huiru gao, liying shan xue li, fengjun gu, hui zhuang#, lijun sun#. prognostic significance of end-stage liver diseases, respiratory tract infection and chronic kidney diseases in symptomatic acute hepatitis e. frontiers in cellular and infection microbiology. 2021; 10:593674. jcr if:6.1; first author and co-corresponding author 研究论文
[38] huahao fan*, luhua qiao*, kyung-don kang, junfen fan, wensheng wei, and guangxiang luo. attachment and post-attachment receptors important for hepatitis c virus infection and cell-to-cell transmission. journal of virology 2017; 91(13):e00280-17. jcr if:6.5; top journal; co-first author 研究论文
[39] pengjun han, yunjia hu, xiaoping an, lihua song#, huahao fan#, yigang tong#. biochemical and genomic characterization of a novel bacteriophage buct555 lysing stenotrophomonas maltophilia. virus research. 2021; 301:198465. jcr if:6.3; co-corresponding author 研究论文
[40] zhen cai, tianye jia, mingfang pu, shuyong zhang, jingxia zhang, ronghua geng, suming chen, yahao li, huahao fan*, yigang tong*, fen qu*. clinical and molecular analysis of st11-k47 carbapenem-resistant hypervirulent klebsiella pneumoniae: a strain causing liver abscess. pathogens. 2022; 11(6):657. jcr if:4.5; co-corresponding author 研究论文
[41] fuxing lou*, hongbo qin*, shiting he*, xiaoping an, lihua song#, yigang tong#, huahao fan#. the benefits of breastfeeding still outweigh the risks of covid-19 transmission. frontiers in medicine. 2021; 8:703950. jcr if:5.1; corresponding author 长篇综述
[42] yinuo zhu, ke han, long chen#, shizhong luo#, huahao fan#, yigang tong#. biological characterization and genomic analysis of acinetobacter baumannii phage buct628. archives of virology. 2022 apr 19. doi: 10.1007/s00705-022-05425-7. jcr if:2.7; co-corresponding author 研究论文
[43] ke han, yinuo zhu, fei li, mengzhe li, xiaoping an, lihua song#, huahao fan#, yigang tong#. genomic analysis of acinetobacter phage buct629, a newly isolated member of the genus obolenskvirus. archives of virology. 2022; 167(4):1197-1199. jcr if:2.7; co-corresponding author 研究论文
[44] ke han, yinuo zhu, fei li, mengzhe li, xiaoping an, lihua song#, huahao fan#, yigang tong#. genomic analysis of bacteriophage buct86 infecting klebsiella pneumoniae. microbiology resource announcement. 2022 apr 11;e0123821. jcr if:0.8; co-corresponding author 基因组报告
[45] rujia chen, xuling xu, pengjun han, yunjia hu, hongbo qin, mengzhe li, xiaoping an, lihua song#, huahao fan#, yigang tong#. complete genome sequence of aeromonas hydrophila bacteriophage buct552. microbiology resource announcement. 2022 feb 17;11(2):e0117221. jcr if:0.8; co-corresponding author 基因组报告
[46] yunjia hu*, shanwei tong*, ping li*, xiaoping an, lihua song#, xinglou yang#, huahao fan#, yigang tong#. characterization and genome sequence of a genetically unique escherichia bacteriophage vb_ecom_ime392. archives of virology. 2021; 166(9):2505-2520. jcr if:2.7; co-corresponding author 研究论文
[47] shengdong luo*, shanshan lu*, huahao fan*, zhihui sun, yan hu, ruisheng li, xiaoping an, vladimir n uversky, zeliang chen#, yigang tong#, lihua song#. he coxiella burnetii qph1 plasmid is a virulence factor for colonizing bone marrow-derived murine macrophages. journal of bacteriology. 2021; 203(9):e00588-20. jcr if:3.5; co-first author 研究论文
[48] huan zhang*, huanying zheng*, jinying zhu*, qiao dong*, jin wang*, huahao fan*, yangzhen chen*, xi zhang, xiaohu han, qianlin li, jiahai lu#, yigang tong#, zeliang chen#. the ubiquitin-modified proteome of sars-cov-2-infected host cells reveals insights into virus-host interaction and pathogenesis. journal of proteome research. 2021; 20(5):2224-2239. jcr if:5.4; co-first author 研究论文
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